Treatment strategies in mucous membrane pemphigoid

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Treatment strategies in mucous membrane pemphigoid

Mucous membrane pemphigoid (MMP) is an autoimmune blistering disorder that is characterized by subepithelial bullae. Various basement membrane zone components have been identified as targets of autoantibodies in MMP. Considerable variability exists in the clinical presentation of MMP. Mucous membranes that may be involved include the oral cavity, conjunctiva, nasopharynx, larynx, esophagus, gen...

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Mucous membrane pemphigoid

Introduction Identifying risk factors for leprosy reactions can preempt clinicians to initiate prompt treatment to prevent associated morbidities. Thus, a retrospective study was done to elucidate the risk factors among 44 newly diagnosed leprosy patients in Sarawak General Hospital from 1993 to 2007. Materials and methods Case folders were searched for demographic data, clinical characteristic...

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Successful treatment of mucous membrane pemphigoid with bortezomib

BP: bullous pemphigoid MMP: mucous membrane pemphigoid INTRODUCTION Mucous membrane pemphigoid (MMP) is a rare, autoantibody-mediated disease characterized by mucocutaneous blistering including oral, ocular, laryngeal, and skin involvement. Treating MMP is challenging, with few effective therapies available. We report successful treatment of a patient with treatment-refractory MMP with the prot...

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Successful treatment of mucous membrane pemphigoid with infliximab.

Our patient was diagnosed with cicatricial pemphigoid (CP) in 2001. She demonstrated classic clinical findings and underwent biopsies that supported this diagnosis. She unfortunately experienced severe CP involving both of her eyes, oral mucosa, pharyngeal mucosa, and esophagus. Her left eye was seriously affected early in the course of her disease. She experienced significant scarring of the c...

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Mucous membrane pemphigoid with severe esophageal stricture.

Mucous membrane pemphigoid (MMP) is a rare nosological entity. MMP consists of a clinical phenotype in which several autoimmune subepidermal bullous diseases are classified. It occurs predominantly in the mucous membranes and usually results in scarring. Esophageal involvement in MMP is rare and is generally seen in patients in whom lesions are widespread. The most common alterations are multip...

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ژورنال

عنوان ژورنال: Therapeutics and Clinical Risk Management

سال: 2008

ISSN: 1178-203X

DOI: 10.2147/tcrm.s1140